Invention Grant
- Patent Title: 2′F-ANA-LET7 mediated utrophin upregulation for DMD therapy
-
Application No.: US16982467Application Date: 2019-03-18
-
Publication No.: US12104152B2Publication Date: 2024-10-01
- Inventor: Tejvir S. Khurana , Manoj Kumar Mishra , Veenu Aishwarya
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , AUM LifeTech, Inc
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania,AUM LifeTech, Inc
- Current Assignee: The Trustees of the University of Pennsylvania,AUM LifeTech, Inc
- Current Assignee Address: US PA Philadelphia; US PA Philadelphia
- Agency: PEARL COHEN ZEDEK LATZER BARATZ LLP
- Agent Mark S. Cohen
- International Application: PCT/US2019/022826 2019.03.18
- International Announcement: WO2019/183005A 2019.09.26
- Date entered country: 2020-09-18
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61P21/00 ; C12N15/113
Abstract:
The invention relates to compositions and methods for enhancing or upregulating utrophin protein production and methods for treating myopathies, such as Duchenne Muscular Dystrophy (DMD). Specifically, the invention relates to compositions, such as oligonucleotides, and methods for enhancing or upregulating utrophin in a subject by blocking binding of let-7c miRNA to the utrophin mRNA 3 untranslated region (UTR).
Public/Granted literature
- US20210040481A1 2'F-ANA-LET7 MEDIATED UTROPHIN UPREGULATION FOR DMD THERAPY Public/Granted day:2021-02-11
Information query
