A whole vehicle in-loop test system of an intelligent automobile, including: a rotary drum platform, used for simulating a longitudinal movement of a test vehicle; an environment perception platform, disposed at a front end of the rotary drum platform, used for simulating a transverse movement of a test vehicle, and including a support base at a lower portion and a vehicle placing platform at an upper portion, where a transverse drive wheel is mounted at the lower portion of the support base, and the transverse drive wheel moves along a transverse track disposed on the ground; and a target vehicle simulation unit, disposed at a periphery of the environment perception platform, and configured to simulate a target vehicle.