Invention Grant
- Patent Title: Biological nanopores having tunable pore diameters and uses thereof as analytical tools
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Application No.: US17269771Application Date: 2019-09-11
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Publication No.: US12105079B2Publication Date: 2024-10-01
- Inventor: Gang Huang , Giovanni Maglia
- Applicant: Rijksuniversiteit Groningen
- Applicant Address: NL Groningen
- Assignee: Rijksuniversiteit Groningen
- Current Assignee: Rijksuniversiteit Groningen
- Current Assignee Address: NL Groningen
- Agency: Wilson Sonsini Goodrich & Rosati
- Priority: EP 193722 2018.09.11
- International Application: PCT/NL2019/050588 2019.09.11
- International Announcement: WO2020/055246A 2020.03.19
- Date entered country: 2021-02-19
- Main IPC: G01N33/487
- IPC: G01N33/487 ; C07K14/435 ; G01N27/447
Abstract:
The invention relates to the field of nanopores, in particular to engineered Fragaceatoxin C (FraC) nanopores and their application in analyzing biopolymers and other (biological) compounds, such as single-molecule (protein) sequencing. Provided is a system comprising oligomeric FraC nanopores comprised in a lipid bilayer, wherein the sum of the nanopore fraction in the heptameric (Type II) state and the nanopore fraction in the hexameric (Type III) state represents at least 60% of the total number of FraC nanopores.
Public/Granted literature
- US20210325365A1 BIOLOGICAL NANOPORES HAVING TUNABLE PORE DIAMETERS AND USES THEREOF AS ANALYTICAL TOOLS Public/Granted day:2021-10-21
Information query
