Embodiments described herein relate generally to electrochemical cells including a selectively permeable membrane and systems and methods for manufacturing the same. In some embodiments, the selectively permeable membrane can include a solid-state electrolyte material. In some embodiments, electrochemical cells can include a cathode disposed on a cathode current collector, an anode disposed on an anode current collector, and the selectively permeable membrane disposed therebetween. In some embodiments, the cathode and/or anode can include a slurry of an active material and a conductive material in a liquid electrolyte. In some embodiments, a catholyte can be different from an anolyte. In some embodiments, the catholyte can be optimized to improve the redox electrochemistry of the cathode and the anolyte can be optimized to improve the redox electrochemistry of the anode. In some embodiments, the selectively permeable membrane can be configured to isolate the catholyte from the anolyte.