Invention Grant
- Patent Title: Rat model of IgA nephropathy induced with a multimeric recombinant IgA fragment
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Application No.: US17155870Application Date: 2021-01-22
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Publication No.: US12108745B2Publication Date: 2024-10-08
- Inventor: Jing Jin , Xinfang Xie
- Applicant: Northwestern University
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Benesch Friedlander Coplan & Aronoff LLP
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C07K14/36 ; C07K16/00 ; C07K19/00 ; G01N33/50
Abstract:
Recombinant poly-IgA oligomers that form high-order oligomers resembling poly-IgA of IgA nephropathy are provided. Injection of recombinant IgA oligomers in an animal model produces prominent renal glomerular mesangial deposition of recombinant poly IgA oligomer, as in IgA nephropathy patients. Thus, producing a model of IgAN pathology that is able to provide screening and evaluation of therapeutic drugs and diagnostic tests.
Public/Granted literature
- US20210364500A1 Rat Model of IgA Nephropathy Induced with a Multimeric Recombinant IgA Fragment Public/Granted day:2021-11-25
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