A method and system for calibrating cameras of a monitoring system, the method comprises receiving a plurality of video frames including a wide area view of a patient area from a primary camera of a monitoring subsystem and a view of a region of interest within the patient area from a secondary camera of the monitoring subsystem, detecting a patient event based on an analysis of given ones of the plurality of video frames corresponding to the wide area view, transmitting the given ones of the plurality of video frames and an identification of the patient event to a viewer client device, generating detection-based calibration instructions based on the patient event, wherein the detection-based calibration instructions including control information that controls operation of the secondary camera based on a location of the patient event, and transmitting the detection-based calibration instructions to the monitoring subsystem, wherein the monitoring subsystem configures the secondary camera based on the control information of the detection-based calibration instructions.