Invention Grant
- Patent Title: Liquid pharmaceutical composition
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Application No.: US17979309Application Date: 2022-11-02
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Publication No.: US12109267B2Publication Date: 2024-10-08
- Inventor: Gianluca Rinaldi , Silvia Fratarcangeli , Alessandra Del Rio
- Applicant: Fresenius Kabi Deutschland GmbH
- Applicant Address: DE Bad Homburg
- Assignee: Fresenius Kabi Deutschland GmbH
- Current Assignee: Fresenius Kabi Deutschland GmbH
- Current Assignee Address: DE Bad Homburg
- Agency: Goodwin Procter LLP
- Priority: EP 169754 2014.05.23
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K9/00 ; A61K47/18 ; A61K47/26 ; C07K16/24

Abstract:
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.
Public/Granted literature
- US20230338527A1 LIQUID PHARMACEUTICAL COMPOSITION Public/Granted day:2023-10-26
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