- Patent Title: Cosmetic compositions comprising low molecular weight silk fibroin
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Application No.: US17287058Application Date: 2019-10-08
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Publication No.: US12109295B2Publication Date: 2024-10-08
- Inventor: Han Cao , Hong Chen , Xin Chen , Amitava Pramanik , Zhengzhong Shao , Jinrong Yao , Weizheng Zhou
- Applicant: Conopco, Inc.
- Applicant Address: US NJ Englewood Cliffs
- Assignee: Conopco, Inc.
- Current Assignee: Conopco, Inc.
- Current Assignee Address: US NJ Englewood Cliffs
- Agency: Foley & Lardner LLP
- Priority: WO TCN2018111503 2018.10.23 EP 208334 2018.11.26
- International Application: PCT/EP2019/077177 2019.10.08
- International Announcement: WO2020/083636A 2020.04.30
- Date entered country: 2021-04-20
- Main IPC: A61K8/64
- IPC: A61K8/64 ; A61Q5/00 ; A61Q5/02

Abstract:
The invention relates to a cosmetic composition comprising a low molecular weight silk fibroin and a cosmetically acceptable carrier; wherein said low molecular weight silk fibroin comprises at least 85 parts by weight peptides of molecular weight less than 2500 Da, where amino acid sequence of at least 50 wt % of said peptides is GAGY, GAGAGAGY, GAGVGAGY or AWSSESDF and where said silk fibroin is produced by a process comprising the steps of: (i) mixing an aqueous solution comprising 0.01 to 20 wt % of a high molecular weight silk fibroin of weight average molecular weight 6 to 100 KDa with ochymotrypsin at temperature of 25 to 45° C., under pH of 6 to 9 for 4 to 24 hours; where ratio of said high molecular weight silk fibroin to said ochymotrypsin in said solution is from 100:1 to 300:1 parts by weight: (ii) inactivating excess ochymotrypsin and separating the inactivated α-chymotrypsin from reaction mixture of step (i); and (ill) drying said reaction mixture to obtain said low molecular weight silk fibroin; wherein said composition comprises 0.1 to 10% by weight of the low molecular weight silk fibroin.
Public/Granted literature
- US20210378935A1 COSMETIC COMPOSITIONS COMPRISING LOW MOLECULAR WEIGHT SILK FIBROIN Public/Granted day:2021-12-09
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