Systems and methods for resolving data (DQ) line swapping configuration in Double Data Rate (DDR) memories are described. In an illustrative, non-limiting embodiment, a system may include a memory controller and a memory coupled to the memory controller, the memory having program instructions stored thereon that, upon execution, cause the system to: apply a first technique to resolve DQ line swapping between a memory interface and a memory module with respect to a first subset of a plurality of DQ lines; apply a second technique different than the first technique to resolve DQ line swapping with respect to a second subset of the plurality of DQ lines; and apply a third technique different than the first and the second techniques to resolve DQ line swapping with respect to a third subset of the plurality of DQ lines.