The present invention discloses an analog-to-digital conversion circuit having quick tracking mechanism is provided. A positive and a negative capacitor arrays receive a positive and a negative input voltages and output a positive and a negative output voltages. A first and a second comparators performs comparison thereon respectively according to and not according to a reference voltage to generate a first and a second comparison results. A control circuit does not perform level-shifting when a difference between the positive and the negative output voltages is not within a predetermined range. The control circuit assigns the positive and the negative capacitor arrays a voltage up-tracking direction and a voltage down-tracking direction respectively to switch a capacitor enabling combination with digital codes according to the second comparison result, and outputs the digital codes as a digital output signal when the positive and the negative output voltages equal.