Invention Grant
- Patent Title: Electrophilic androgen receptor (AR) antagonists for AR downregulation and ferroptosis induction in cancer cells
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Application No.: US17071896Application Date: 2020-10-15
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Publication No.: US12133846B2Publication Date: 2024-11-05
- Inventor: Zhihui Qin , Liping Xu
- Applicant: WAYNE STATE UNIVERSITY
- Applicant Address: US MI Detroit
- Assignee: WAYNE STATE UNIVERSITY
- Current Assignee: WAYNE STATE UNIVERSITY
- Current Assignee Address: US MI Detroit
- Agency: Lee & Hayes, P.C.
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/198 ; A61K47/54
Abstract:
Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.
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Information query
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