Invention Grant
- Patent Title: Pharmaceutical compositions having a selected release duration
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Application No.: US18331741Application Date: 2023-06-08
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Publication No.: US12133878B2Publication Date: 2024-11-05
- Inventor: Yuhua Li , Andrew J. Guarino
- Applicant: Foresee Pharmaceuticals Co., Ltd.
- Applicant Address: TW Taipei
- Assignee: Foresee Pharmaceuticals Co., Ltd.
- Current Assignee: Foresee Pharmaceuticals Co., Ltd.
- Current Assignee Address: TW Taipei
- Agency: MagStone Law, LLP
- Agent Enshan Hong
- Main IPC: A61K38/09
- IPC: A61K38/09 ; A61K9/00 ; A61K47/22 ; A61K47/34

Abstract:
The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a strong acid salt and a weak acid of a LHRH agonist or antagonist; b) a biodegradable polymer of poly(lactide-co-glycolide), wherein the ratio of lactide:glycolide of the copolymer is from 50:50 to about 100:0; and c) N-methyl-2-pyrrolidone (NMP), wherein the composition does not contain excess strong acid in addition to the strong acid used to form the salt of the LHRH agonist or antagonist. The composition, when injected, can provide a controlled release of leuprolide for a period of up to 6 months.
Public/Granted literature
- US20230346877A1 Pharmaceutical Compositions having a Selected Release Duration Public/Granted day:2023-11-02
Information query
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