Invention Grant
- Patent Title: Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules
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Application No.: US15579556Application Date: 2016-05-26
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Publication No.: US12133911B2Publication Date: 2024-11-05
- Inventor: Michael Mark Morgen , Aaron Keith Goodwin
- Applicant: Capsugel Belgium NV
- Applicant Address: BE Bornem
- Assignee: Capsugel Belgium NV
- Current Assignee: Capsugel Belgium NV
- Current Assignee Address: BE Bornem
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/IB2016/053085 WO 20160526
- International Announcement: WO2016/198983 WO 20161215
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/16 ; A61K9/48 ; A61K31/4166

Abstract:
Disclosed are dosage forms comprising a capsule and a fill material, comprising (a) a fill material comprising a dispersion of an active agent and a polymer, the dispersion being granulated, (b) an osmogen, and (c) a glidant. In one embodiment, the dispersion comprises 10 wt % to 90 wt % of the fill material, the osmogen comprises from 5 wt % to 40 wt % of the fill material, and the glidant comprises at least 0.1 wt % of the fill material.
Public/Granted literature
- US20180161269A1 FORMULATIONS TO ACHIEVE RAPID DISSOLUTION OF DRUG FROM SPRAY-DRIED DISPERSIONS IN CAPSULES Public/Granted day:2018-06-14
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