A device and associated method for centrifuging a physiological fluid includes a syringe including a tip, a base and a barrel extending between the tip and the base to hold a physiological fluid. The syringe includes a plunger positioned within the barrel and the plunger includes a plunger seal in sealing engagement with an inside wall of the barrel. An exoskeleton is provided to support the syringe at least partially within the exoskeleton for use in a centrifuge. The syringe is removably coupled to the exoskeleton using an interference fit. The method includes holding the physiological fluid in the syringe, supporting the syringe at least partially within the exoskeleton, and centrifuging the physiological fluid in the syringe supported by the exoskeleton.