Devices, systems, and methods for blister packaging are disclosed. An assembly utilizing interchangeable inserts allows for a variety of blister packaging to be sealed with corresponding labels that are anchored into proper orientation through the use of locator pins. Blisters are nested into inserts and held in a fixed position while label sheets having holes for receiving locator pins are inserted onto the assembly. Visual indicators on labels identify pull flaps, and tear slits provide evidence of tampering with packaged blisters.