![Crystalline salts or co-crystals of 2′,6-difluoro-5′-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile with p-toluenesulofonic acid as GABAA positive allosteric modulators](/docs/US/2024-11-05/US12134619B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline salts or co-crystals of 2′,6-difluoro-5′-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile with p-toluenesulofonic acid as GABAA positive allosteric modulators
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Application No.: US18089661Application Date: 2022-12-28
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Publication No.: US12134619B2Publication Date: 2024-11-05
- Inventor: Matthew Toczko , Jed Hubbs
- Applicant: NeuroCycle Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: NeuroCycle Therapeutics, Inc.
- Current Assignee: NeuroCycle Therapeutics, Inc.
- Current Assignee Address: US CA San Diego
- Agency: K&L Gates LLP
- Main IPC: A61K31/53
- IPC: A61K31/53 ; C07D487/04
![Crystalline salts or co-crystals of 2′,6-difluoro-5′-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile with p-toluenesulofonic acid as GABAA positive allosteric modulators](/abs-image/US/2024/11/05/US12134619B2/abs.jpg.150x150.jpg)
Abstract:
Described herein are polymorphs comprising 2′,6-difluoro-5′-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with p-toluenesulfonic acid of the following formula: Also described herein are methods of making and using the same.
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