- Patent Title: Methods of predicting ancestral virus sequences and uses thereof
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Application No.: US18308590Application Date: 2023-04-27
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Publication No.: US12134786B2Publication Date: 2024-11-05
- Inventor: Luk H. Vandenberghe , Eric Zinn
- Applicant: Massachusetts Eye and Ear Infirmary , The Schepens Eye Research Institute, Inc.
- Applicant Address: US MA Boston; US MA Boston
- Assignee: Massachusetts Eye and Ear Infirmary,The Schepens Eye Research Institute, Inc.
- Current Assignee: Massachusetts Eye and Ear Infirmary,The Schepens Eye Research Institute, Inc.
- Current Assignee Address: US MA Boston; US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: A61K39/23
- IPC: A61K39/23 ; A61K39/00 ; C07K14/00 ; C07K14/005 ; C07K16/22 ; C12N7/00 ; C12N15/86
Abstract:
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
Public/Granted literature
- US20230287359A1 METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF Public/Granted day:2023-09-14
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