Example computer-implemented methods, media, and systems for processing input/output (I/O) commands using block size aware polling are disclosed. One example method includes creating multiple polling queues and multiple interrupt queues in a transport drivers layer of a storage stack. A first I/O command is received from a core layer of the storage stack and by the transport drivers layer. A ratio of a total number of multiple small block size commands in the transport drivers layer to a total number of multiple outstanding I/O commands in the transport drivers layer is determined to be larger than a predetermined first threshold. In response to determining that the ratio is larger than the predetermined first threshold, the polling mode is applied to the first I/O command through the submission of the first I/O command to a first polling queue in the multiple polling queues.