Systems and methods provided for vulnerability proofing updates to an IHS (Information Handling System). Upon receipt of an update to hardware component configurations of the IHS, vulnerability proofing requirements for modifications to the hardware component configurations are retrieved, including requirements for modifications that are validated for operation of a computational workload by the IHS. Based on the vulnerability proofing requirements, catalogs specifying known vulnerabilities of hardware components are consulted to determine whether the modifications are identified as vulnerable in the catalogs and whether remediations to the identified vulnerabilities are validated for operation of the workload. If the modifications are not identified as vulnerable in the catalogs, the update is transmitted to the IHS. If the modifications are identified as vulnerable in the catalogs and remediations to the identified vulnerabilities are not validated for operation of the workload, the update is terminated.