Systems and methods are provided that may be implemented in one example to physically transfer or relocate information handling systems between facilities of different system owners in a manner that is downstream of the original equipment manufacturer (OEM) of the transferred information handling system/s, and which in one example may be managed in part or in whole by the OEM's customer base. In conjunction with facilitating physical transfer of each given information handling system directly between different enterprise owners, the disclosed systems and methods may also be implemented at the same time to utilize a unique identifier (that is assigned by the OEM manufacturer to each given information handling system) to manage transfer of the registration or other type of association of the given information handling system assets between the enterprise OEM user accounts of the different enterprise owners that are maintained by an OEM of the information handling system assets.