Systems and methods of message filtering in a multi-region multi-active architecture. A client device via a client application receives a data message associated with a topic subscribed by the client application from an application service provider. The data message includes a region tag associated with a region server producing the data message and an account tag representing a group of client accounts associated with the data message. The client device determines whether the region tag corresponds to a home region server assigned to the client application. In response to determining the region tag corresponds to the home region server assigned to the client application, the client device determines whether an account identification (ID) corresponding to the client application matches the account tag in the data message. In response to determining the account ID matches the account tag, the client device consumes the data message.