Systems/techniques that facilitate machine learning generation of low-noise and high structural conspicuity images are provided. In various embodiments, a system can access an image and can apply at least one of image denoising or image resolution enhancement to the image, thereby yielding a first intermediary image. In various instances, the system can generate, via execution of a plurality of machine learning models, a plurality of second intermediary images based on the first intermediary image, wherein a given machine learning model in the plurality of machine learning models receives as input the first intermediary image, wherein the given machine learning model produces as output a given second intermediary image in the plurality of second intermediary images, and wherein the given second intermediary image represents a kernel-transformed version of the first intermediary image. In various cases, the system can generate a blended image based on the plurality of second intermediary images.