Systems and methods for detecting improper presentation of content items by applications executing on client devices. A method can include: (i) receiving content requests from a plurality of client devices, wherein each of the content requests is generated by an application executing on a respective client device of the plurality of client devices; (ii) transmitting to each client device of the plurality of client devices, responsive to a content request from the client device, a content package including at least a content item and an interaction confirmation script; (iii) determining a location parameter associated with the interaction confirmation script; (iv) determining a performance metric of the content item; and (v) determining whether the application receives inadvertent clicks at the content item based on the performance metric and the location parameter.