Invention Grant
- Patent Title: Aryl hydrocarbon receptor modulators and uses thereof
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Application No.: US18181099Application Date: 2023-03-09
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Publication No.: US12152016B2Publication Date: 2024-11-26
- Inventor: Elliot Chaikof , Lijun Sun
- Applicant: Beth Israel Deaconess Medical Center, Inc.
- Applicant Address: US MA Boston
- Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee: Beth Israel Deaconess Medical Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D403/06
- IPC: C07D403/06 ; A61P29/00 ; C07D209/12 ; C07D401/06 ; C07D409/06 ; C07D471/04

Abstract:
Provided are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, isotopically labeled derivatives, polymorphs, and prodrugs thereof, wherein X1-X4, RX, RC, RB, n, and Ring A are as defined herein. The compounds may be aryl hydrocarbon receptor agonists or partial aryl hydrocarbon receptor agonists. Also provided are pharmaceutical compositions comprising a compound of Formula (I) and methods of using such compounds for treating diseases and conditions related to the activity of an aryl hydrocarbon receptor, such as, for example, inflammatory diseases, autoimmune diseases, metabolic disorders, and proliferative diseases.
Public/Granted literature
- US20230278986A1 ARYL HYDROCARBON RECEPTOR MODULATORS AND USES THEREOF Public/Granted day:2023-09-07
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