A method of transmitting and receiving downlink control information (DCI) in a wireless communication system and a device therefor are disclosed. Specifically, a method of receiving downlink control information (DCI) by a user equipment (UE) in a wireless communication system, the method comprises receiving configuration information related to a search space; determining PDCCH candidates to be monitored within a plurality of search spaces, wherein the plurality of search spaces are configured for a plurality of control resource sets (CORESETs) based on the configuration information, and each search space includes one or more physical downlink control channel (PDCCH) candidates; monitoring the PDCCH candidates to be monitored; and receiving the DCI based on the monitoring.