The present disclosure relates to methods and devices for dynamic resource multiplexing. In one aspect, a base station can transmit a first uplink/downlink configuration for communicating with one or more User Equipments (UEs). The first uplink/downlink configuration can comprise a set of fixed resources configured for uplink communication without downlink resources for downlink communication or for downlink communication without uplink resources for uplink communication. The base station can also transmit a second uplink/downlink configuration for communicating with the one or more UEs. The second configuration can comprise a flexible resource configuration. Additionally, the base station can communicate with a least one of the one or more UEs based on the first uplink/downlink configuration or the second uplink/downlink configuration.