An airlift bioreactor includes a body, a first sparging region, a second sparging region, a first sparger configured to sparge a first gas within the first sparging region, a second sparger configured to sparge a second gas within sparging region, and a controller coupled to the first sparger and the second sparger. The controller is configured to control a first flow rate associated with the first sparger and a second flow rate associated with the second sparger.