A method for data access control among multiple nodes and a data access system are provided. The data access system includes a data interconnect controller circuit that allocates resources of one or more slaves by one or more masters according to operating parameters of an interleaver, and includes an intelligent control module that collects use efficiency data of the one or more slaves and obtains a current setting of the data interconnect controller circuit via a monitor. The monitor calculates scores of use efficiency data. The scores and the setting are inputted to a neural network model. Parameters of the neural network model are adjusted according to the scores, and a new setting generated by the neural network model is applied to the interleaver of the data interconnect controller circuit, so that the data interconnect controller circuit performs access control among the multiple nodes with the new setting.