Techniques for generating a synthetic computed tomography (sCT) image from a cone-beam computed tomography (CBCT) image are provided. The techniques include receiving a CBCT image of a subject; generating, using a generative model, a sCT image corresponding to the CBCT image, the generative model trained based on one or more deformable offset layers in a generative adversarial network (GAN) to process the CBCT image as an input and provide the sCT image as an output; and generating a display of the sCT image for medical analysis of the subject.