Invention Grant
- Patent Title: Phage-displayed accessible recombinant targeted antibodies and methods of making same
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Application No.: US18047533Application Date: 2022-10-18
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Publication No.: US12168685B2Publication Date: 2024-12-17
- Inventor: Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R. M. Bradbury
- Applicant: Rutgers, The State University of New Jersey
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Saul Ewing LLP
- Agent Domingos J. Silva; Lukas W. Pffanenshiel
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K38/07 ; A61K39/00 ; A61K39/395 ; A61K47/68 ; A61K49/00 ; A61P35/00 ; C07K14/47 ; C07K16/00 ; C07K16/28 ; C07K16/30 ; C12N15/10 ; C12N15/64 ; C12Q1/6869 ; G01N33/50 ; G01N33/574
Abstract:
Isolated or recombinant EphA5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
Public/Granted literature
- US20230139913A1 Phage-Displayed Accessible Recombinant Targeted Antibodies and Methods of Making Same Public/Granted day:2023-05-04
Information query
