- Patent Title: Bispecific antibodies which bind blood coagulation factor VIII and have enhanced activity, and methods of use thereof for treating bleeding and associated conditions
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Application No.: US17563149Application Date: 2021-12-28
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Publication No.: US12168697B2Publication Date: 2024-12-17
- Inventor: Tomoyuki Igawa , Yuri Teranishi
- Applicant: Chugai Seiyaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2015-253324 20151225
- Main IPC: C07K16/36
- IPC: C07K16/36
Abstract:
As a result of producing ACE910 variants in which various sites of the constant regions were modified, the inventors discovered bispecific antibodies having FVIII mimetic activity higher than that of ACE910. The inventors also identified mutation positions that elevate the FVIII mimetic activity and discovered methods for elevating the FVIII mimetic activity by using the mutations.
Public/Granted literature
- US20220119551A1 ANTIBODY HAVING ENHANCED ACTIVITY, AND METHOD FOR MODIFYING SAME Public/Granted day:2022-04-21
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