Invention Grant
- Patent Title: Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture
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Application No.: US17292302Application Date: 2019-11-06
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Publication No.: US12168791B2Publication Date: 2024-12-17
- Inventor: László Párta , Ákos Putics , Tibor Balogh , Balázs Horváth , Gáspár Nagy
- Applicant: RICHTER GEDEON NYRT.
- Applicant Address: HU Budapest
- Assignee: RICHTER GEDEON NYRT.
- Current Assignee: RICHTER GEDEON NYRT.
- Current Assignee Address: HU Budapest
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: HU1800376 20181107
- International Application: PCT/EP2019/080342 WO 20191106
- International Announcement: WO2020/094694 WO 20200514
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N5/00
Abstract:
The present invention relates to a method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture comprising culturing eukaryotic cells expressing the recombinant glycoprotein in a cell culture medium, wherein the cell culture medium is supplemented with fucose, manganese, and taurine, wherein the glycosylation profile of the produced recombinant glycoprotein is modified to better resemble the glycosylation profile of a reference glycoprotein than when cultured without said supplementation.
Public/Granted literature
- US20220098634A1 METHOD FOR MODIFYING THE GLYCOSYLATION PROFILE OF A RECOMBINANT GLYCOPROTEIN PRODUCED IN CELL CULTURE Public/Granted day:2022-03-31
Information query
