The present disclosure relates to an adaptive body biasing or voltage regulation circuit for a circuit region, comprising: a first delay module configured to delay a local clock signal to generate first and second output signals delayed by first and second delays; a multiplexer configured to select one of the first and second output signals; a first slack monitor circuit configured to generate a first detection signal indicating when a slack time of the first and second output signals is less than a first threshold; a voltage generation circuit configured to generate a supply voltage for the circuit region, or at least one biasing voltage for biasing wells of transistors in the circuit region, using a further control loop comprising a process, voltage and/or temperature sensor; and a control circuit configured to adjust a gain of the further control loop based on the first detection signal.