Systems and methods for re-purposing autonomous vehicle for package transportation are disclosed. In one embodiment, a method is disclosed comprising receiving a request from an autonomous vehicle; identifying, responsive to the request, a nearby package stored within a delivery structure; transmitting routing instructions to the autonomous vehicle, the routing instructions including a location of the delivery structure; detecting a presence of the autonomous vehicle; instructing the delivery structure to deposit the nearby package into the autonomous vehicle; calculating a waypoint for delivery of the nearby package; and transmitting transport routing instructions to the autonomous vehicle, the transport routing instructions including the waypoint.