Systems and methods provide vulnerability proofing procedures for booting of an IHS (Information Handling System). A request to boot the IHS is detected. One or more boot configurations are determined that include configurations for operation of one or more of the hardware components of the IHS. One or more catalogs are accessed that specify known vulnerabilities of hardware components. The boot configurations are used to identify any hardware component configurations that have known vulnerabilities that are listed in the catalogs. If known vulnerabilities are identified in the boot configuration, further booting of the IHS may be disabled until the boot configuration is modified to include no configurations with vulnerabilities identified in the catalogs.