Systems and methods for performing a quantization of artificial neural networks (ANNs) are provided. An example method may include receiving a description of an ANN and sets of inputs to neurons of the ANN, the description including sets of weights of the inputs, the weights being of a first data type, determining a first interval of the first data type to be mapped to a second interval of a second data type; performing computations of sums of products of the weights and the inputs to obtain a set of sum results, wherein the computations are performed using at least one number within the second interval, the number being a result of mapping of a number of the first interval to a number of the second interval, determining a measure of saturations in sum results, and adjusting, based on the measure of saturations, one of the first and second intervals.