A method and a system are described for dynamic range enhancement in CMOS image sensors using charge-transfer amplification. The method involves resetting a pixel array and other nodes of the CMOS image sensor. It involves receiving light for a predetermined duration on the pixel array layered with photodiodes. It involves configuring an integration time of incident light at the photodiodes 104, for a desired exposure and releasing photoelectrons to form a current signal. An equivalent voltage signal is built allowing a voltage build-up by charging a storage capacitance, and thereafter adjusting the voltage build-up by adjusting a ratio between the storage capacitance and amplification capacitance. The voltage signal is then integrated with the current signal in order to obtain an integrated signal of amplified gain, and the method involves generating a resultant electronic signal with a higher amplification factor and an enhanced gain as compared to the input electronic signal.