Antenna systems with both single-ended and differential signal feeds are provided herein. In certain embodiments, a mobile device includes a front end system including a first radio frequency signal conditioning circuit configured to condition a first radio frequency signal that is single-ended and of a first frequency, and a second radio frequency signal conditioning circuit configured to condition a second radio frequency signal that is differential and of a second frequency. The mobile device further includes an antenna including a first signal feed connected to the first radio frequency signal conditioning circuit and a pair of second signal feeds connected to the second radio frequency signal conditioning circuit.