The disclosed system can determine egress guidance during a building emergency using artificial intelligence (AI). The system can include sensors positioned throughout the building to detect building conditions and a computing system to determine egress guidance in the building. The computing system can perform operations including: receiving, from the sensors, information indicating the building conditions, detecting, based on processing the conditions, an emergency in the building, determining, based on applying AI techniques to the information, scenarios indicating potential spreads of the emergency, generating, based on the determined scenarios, egress guidance to assist users in safely egressing from the building. The egress guidance can include at least one egress strategy instructing the users to move along a pathway that avoids the emergency and the potential spreads of the emergency. The egress guidance can be returned for presentation to the users in the building to assist in safely avoiding the emergency.