A method implemented on a computing device having at least one processor, storage, and a communication platform connected to a network for determining blood pressure includes: receiving a request to determine a blood pressure of a first subject from a terminal, obtaining data relating to the first subject, the data relating to the first subject including data relating to heart activity of the first subject and personal information relating to the first subject, extracting target features relating to the first subject from the data relating to the first subject, determining a preliminary blood pressure of the first subject using a prediction model based on the target features relating to the first subject, determining a predicted blood pressure of the first subject using an optimization model based on the preliminary blood pressure and sending the predicted blood pressure of the first subject to the terminal in response to the request.