Disclosed methods and systems for managing on-premises information handling resources establish, by an in-cloud web portal, an agentless connection to an on-premises information handling resource and perform, via the agentless connection, a configuration management operation to modify a configuration of the on-premises handling resource. Establishing the agentless connection and performing the configuration management operation may include one or more appropriate API calls. Disclosed teachings enable a web-accessible, public cloud portal to perform active configuration management of on-premises resources scattered across any number of distinct and potentially isolated customer sites without deploying and maintaining management agent software within the customer's private cloud. The on-premises resources may include a multi-node cluster provided by a node or nodes of one or more HCI appliances.