A display substrate (1) and a display device, which can reduce the number of power lines (22), and improve the light transmittance of a first display sub-region (111). The display substrate (1) includes a first display sub-region (111) and a second display sub-region (112), where a light transmittance of the first display sub-region (111) is higher than that of the second display sub-region (112); the display substrate (1) includes: a plurality of first-type sub-pixels (21) and a plurality of power lines (22), where the first-type sub-pixels (21) and the power lines (22) are located in the first display sub-region (111); the first-type sub-pixels (21) are arranged in an array along a row direction (X) and a column direction (Y); each first-type sub-pixel (21) comprises a light emitting element and a pixel circuit for driving the light emitting element to emit light; the plurality of power lines (22) are connected to one another; the plurality of power lines (22) comprise at least one of first-type power lines (221) or second-type power lines (222), the first-type power lines (221) are configured to be connected to pixel circuits of the first-type sub-pixels (21) arranged along the row direction (X), and the second-type power lines (222) are configured to be connected to pixel circuits of the first-type sub-pixels (21) arranged in the column direction (Y); a sum of a number of the first-type power lines (221) and a number of the second-type power lines (222) is smaller than a sum of a number of rows and a number of columns of the array.