An OLED display system is provided having visual performance pixel compensation for loss of brightness, including display pixels, where each display pixel has OLED subpixels and pixel drive circuitry; a sensing system having sensors and analog to digital conversion circuitry connected to each of the sensors, and a processor to provide an image data drive signal to each of the display pixels, receive the sensor signal from the ADC circuitry for each sensor, estimate a state of degradation of at least one of the display pixels, determine a drive-signal compensation for each display pixel having an estimated state of degradation and compensate the image data drive signal to each display pixel having an estimated state of degradation. Methods for compensating pixels for an image in a display are also provided.