System-of-systems architectures and methods for dynamically and adaptively managing and executing a command and control system across a global cyber enterprise are provided. The system-of-systems architecture integrates, synchronizes and executes with kinetic operations employing an adaptive and dynamic mixing and matching of capabilities for optimal effects in near real time so as to measure and maximize effects across the global cyber enterprise. The methods incorporate execution of a Cyber Operations “CyberOps” Chain of interlocking management cycles for the integration with a kinetic “Kill Chain” to optimize cyber/kinetic integration and mission outcomes. An analytical and software framework enables the on-demand formation of mission-specific dynamic cell groups from various cells stretching across the global cyber enterprise in response to ever-changing faces of cyber threats.