A system and method for optimizing imaging system parameters includes determining, by a processor, a first set and second set of imaging parameters. An imaging device captures one or more first images according to the first set of imaging parameters while the processor is determining the second set of imaging parameters. The method further includes determining a first score from data associated with the one or more first images, capturing one or more second images according to the second set of imaging parameters, and determining a second score from data associated with the one or more second images. The processor then determines, from the first and second scores, an optimized set of imaging parameters from the first set of imaging parameters and the second set of imaging parameters.