The present disclosure relates to a method and apparatus for applying logical channel restriction in a wireless communication system. According to an embodiment of the present disclosure, an operation method of a terminal in a wireless communication system includes: receiving configuration information associated with restrictions for logical channels; and identifying, based on the configuration information, an uplink resource allocated with a configured scheduling-radio network temporary identifier (CS-RNTI), wherein when a value of a new data indicator (NDI) of the CS-RNTI is 0, the uplink resource is considered as a configured grant.