This disclosure discloses a method and apparatus for determining a quantum circuit. The method may include sampling an initial circuit unit pool according to an initial sampling manner to obtain initial K groups of circuit units and constructing and generating initial K candidate quantum circuits. The method may further include determining a performance evaluation index corresponding to the initial K candidate quantum circuits and updating the initial sampling manner and a circuit unit in the initial circuit unit pool based on the performance evaluation index, to obtain an updated sampling manner and an updated circuit unit pool. The method may further include sampling the updated circuit unit pool according to the updated sampling manner to obtain updated K groups of circuit units and constructing and generating updated K candidate quantum circuits. The method may further include determining a target quantum circuit from the updated K candidate quantum circuits.