Disclosed are systems and methods for user equipment (UE) transmission adaptation after physical uplink shared channel (PUSCH) misdetection. Instead of the cell base station (e.g., gNB) transmitting a new grant with exactly the same parameters as a first grant transmission that failed to receive a response from the user equipment (UE), the gNB transmits a new transmission with an adjusted DCI and/or an adjusted grant to increase a probability that the expected uplink (UL) transmission is received from the UE. For example, a gNB may transmit a new DCI with a new Aggregation Level (AL) indicating a new UL grant to cause one or more of: an increase in UL power spectral density (PSD) on the PUSCH; a reduction in a number of allocated resource blocks (RB); a reduction in transport block size (TBS); a reduction in a Modulation and Coding Scheme (MCS) to use for the UE transmission; and use of different redundancy versions (RV) for retransmissions.