This disclosure provides methods, devices, and systems for low-light imaging. In some implementations, an image processor may be configured to reduce or remove noise associated with an image based, at least in part, on a neural network. For example, the neural network may be trained to infer a denoised representation of the image. In some aspects, the image processor may scale the brightness level of the image to fall within a normalized range of values associated with the neural network. In some other aspects, a machine learning system may scale the brightness levels of input images to match the brightness levels of ground truth images used to train the neural network. Still further, in some aspects, the machine learning system may scale the brightness levels of the input images and the brightness levels of the ground truth images to fall within the normalized range of values during training.