A display substrate and a display device, include: a base substrate, which includes a display area, and a bonding area (BA) disposed on one side of the display area; a plurality of gate lines, a plurality of data lines, a plurality of lead lines, the plurality of lead lines each is respectively electrically connected with a respective one of the plurality of data lines, each of the plurality of lead lines includes a first portion extending in the second direction, and orthographic projections of at least part of the first portions on the base substrate do not overlap with orthographic projections of the data lines on the base substrate.